We conducted a comprehensive study to understand what demographics are involved in motor vehicles-involved e-scooter and bicycle crashes, under what circumstances such crashes occur, and what are the mechanisms of such collisions. In the first-of-its-kind study, we compared and contrasted motor vehicle-involved e-scooter and bicycle police crash reports in Nashville, Tennessee, using the recent version of the Pedestrian and Bicycle Crash Analysis Tool (PBCAT). We found that e-scooter and bicycle crashes do not fully overlap with each other. The findings of the study imply that generalized engineering, education, and enforcement treatments to reduce or prevent e-scooter and bicycle crashes, injuries, and deaths might not yield a similar outcome for each mode. This research-to-practice study could help avoid e-scooter and motor vehicle crashes that contribute to 80% fatality of e-scooter riders.